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What You Need to Generally Know About CBD Dosage

The many CBD oil brands make it difficult to determine the right starting dosage since they are using different standards. We tend to lean on the standards of Nordic Oil, a very reliable CBD brand in Europe. The following article sources Nordic Oil’s wiki page “CBD Dosage – How Much CBD Should I Take?

This article assumes that you, the reader, are already familiar with CBD. If not, please first read our page Cannabidiol: The Ultimate Guide to CBD, which explains that, when beginning CBD, it is best to start with a small dose. It is very important to become familiar with how your body responds to CBD before increasing the dose. We always advise users that every person is different and everyone’s reaction to CBD is different. On an average, 25mg of CBD a day is effective for most people. The dosage of CBD can be increased slowly until the symptoms improve. If a higher dosage is ultimately desired, consider a product with a higher CBD content.

One of the most frequently asked questions from our readers is, “What is the correct daily dosage of CBD for me?” This article goes into a little more detail than our Cannabidiol: The Ultimate Guide to CBD page, but we also have an article specific to Dosages for Vaping. Visit our website again for future articles more specific to dosages for oil and other products.

There are four major ways of taking CBD: edible, topical, sublingual and inhalation.

Given the several uses of CBD, there are many CBD products that are available in the market today. The number of people who are using CBD supplements is increasing on a daily basis.

Products include:

  • Oils, Pastes, Drops
  • Creams, Balms
  • Capsules
  • Tinctures
  • Gum
  • Soaps
  • Vaping liquids
  • Isolates

Note: The Food and Drug Administration (FDA) is responsible for determining the recommended daily dosage of supplements but they are yet to do so with CBD.

As mentioned, when beginning CBD, it is best to start with a small dose. It is very important to become familiar with how your body responds to CBD before increasing the dose. We always advise users that every person is different and everyone’s reaction to CBD is different. On an average, 25mg of CBD a day is effective for most people. The dosage of CBD can be increased slowly until the symptoms improve. If a higher dosage is ultimately desired, consider a product with a higher CBD content.

Note: It is important you know that CBD is not a toxic oil. Your body can, therefore, tolerate it at an incredibly high dosage of 1500 mg daily, which we do not recommend. To ensure you get an accurate CBD vape dosage every day, you could buy a disposable cartridge that comes with standard CBD content and then track the number of puffs you take.

Nordic Oil has put together a simple dosage guide which follows the dosage guide spelled out in a book titled CBD: A Patient’s Guide To Medical Cannabis by Leonard Leinow and Juliana Birnbaum. Leonard Leinow founded Synergy Wellness, a not-for-profit medical cannabis collective in Northern California and has three decades of experience growing and studying medical cannabis. They are specialists in CBD pioneers in this aspect of the industry. Juliana Birnbaum has lived and worked around the world and founded Voices in Solidarity, an initiative that partnered with tribal leaders from the Brazilian Amazon to support the development of a community-led environmental education center.

This book is an excellent resource for those new to CBD and its medicinal properties. The book is full of information about CBD from the history of its use, dosing, studies on its use for a variety of illnesses/conditions, and much more.

Based on Nordic Oil’s guideline and the book, we recommend the step-up approach were you gradually increase the dose until the most desired results are reached. The term used in the book is “Titration.” This is a term borrowed from chemistry that means taking small steps over time in order to allow for adjustment slowly. By using this method, you’re tailoring the amount of the oil to fit your needs. Every person is different and everyone’s reaction to CBD is different.

As there is a wide range of dosing possibilities, the authors have identified three dose ranges that can be useful for different conditions:

There are a number of factors that need to be taken into consideration when finding the perfect dosage of CBD for you. Some of the factors that play an important part in your experience using CBD are:

  • Your medical condition or problem
  • How intense your problem is
  • Metabolism!!!
  • How you respond to CBD
  • Body Weight
  • Sensitivity to cannabis
  • Your personal body chemistry (this includes any other medications you may be taking)

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Will CBD Get You High?

Will CBD get you high? NO! And here’s why…

Because CBD and Tetrahydrocannabinol (THC) are both cannabinoids, meaning that they are both in fact sisters to the mother Cannabis plant, the production of CBD has been somewhat controversial. Once it has been understood that CBD is entirely legal and safe, for it does NOT have psychoactive effects like THC, people still often find this treatment complicated and thus difficult to grasp. For example, according to some users, they experience enhanced relaxation after taking CBD. Non-users might misunderstand said relaxation as “getting high” but that is not the case. CBD simply an adaptogenic substance used in herbal medicine for stabilizing physiological processes and promoting homeostasis. For example, CBD is really effective in treating anxiety (learn more about treating anxiety through Nordic Oil’s wiki page) as oppose to THC which is known for causing anxiety.

We found the following video very helpful in understanding the differences between THC and CBD. The remaining article highlights many key points from the video.

THC versus CBD?

Cannabidiol (CBD) and Tetrahydrocannabinol (THC) are both cannabinoids, meaning that they are in fact sisters to the mother Cannabis plant.

CBD is derived from hemp, one of the oldest crops. Nordic Oil’s wiki page “The History of Hemp” provides an interesting overview, discussing the purposes of hemp in different areas of the world.

The history of the hemp plant stretches back to 10,000 years ago. Carbon tests suggest that Hemp was used as far back as 8,000 B.C. Great Britain’s history indicates that cultivation of hemp has been done since 800 A.D. During the 16th Century Henry VIII told farmers to plant hemp plant in large amounts to offer materials for British Naval fleet. Full grown hemp has a height of 10-15 feet and it has a fibrous trunk to support its weight.

In a nutshell, for thousands of years, we have been producing clothing and paper from hemp, but also medicine, nutritional supplements, baby care products, building materials, plastic composites and more.

On the other hand, marijuana and hashish contain high amounts of THC so that they can be used as an intoxicant. Marijuana is harvested and purchased mainly for its psychoactive and euphoric properties, although its ability to increase appetite by triggering the hypothalamus section in the brain, can be effective in mitigating a loss of appetite and nausea caused by chemotherapy.

The important difference is that CBD is not psychotropic like THC; it does not induce a euphoric effect, otherwise known as a “high”. To elaborate… THC directly interacts with CB1 and CB2 receptors throughout your body whereas CBD works alongside them. To review from our Cannabidiol: The Ultimate Guide to CBD, your body’s endocannabinoid system is involved in regulating pain, immune system, sleep, appetite and much more. So in other words, the body produces endocannabinoids that bind to cannabinoid receptors in your nervous system. CB1 receptors are located in the nervous system (connective tissues, gonads, glands and organs) but there are also CB2 receptors in the immune system (spleen, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs), which is why scientists are, for instance, fascinated with the benefits of CBD for inhibiting the growth of tumors. (Researchers today suspect that there may even be a third cannabinoid receptor which has yet to be discovered!) In other words, the endocannabinoid system regulates many bodily functions. The peculiarity of the cannabinoid receptors is their location. To explain, your nervous system is built of transmitters and receptors, i.e. first and secondary cells. So, normally, receptors are located at the secondary cell to forward the signal on. However, oddly, the cannabinoid receptors are located on the former, i.e. the transmitter cell. This means that CBD is not directly responsible for the forwarding of the signal, but the transmitter cell retrograde, that is, returns information in a retrograde manner. Cannabinoids thus provide feedback to the transmitter cell. The messengers of the endocannabinoid system are therefore referred to as retrograde neurotransmitters or neuromodulators. So although CBD has little direct binding affinity for CB1 and CB2 receptors, it can influence the actual information transferred, also modulating several non-cannabinoid receptors and ion channels. Essentially, CBD works alongside the CB1 and CB2 receptors, such as by enhancing or inhibiting the binding action of certain G-protein coupled receptors. For example, Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London have found that CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect. Another example, CBD binds to TRPV1 receptors, which also function as ion channels, TRPV1 being known for mediating pain perception, inflammation and body temperature. To sum up, THC directly binds to CB1 receptors in the brain. This alters how the brain functions, affecting coordination, pleasure and cognitive abilities, thus causing the high. However, CBD does not directly bind to the CB1 receptors directly but still greatly supports and enhances the whole endocannabinoid system. For this reason, it doesn’t have the psychoactive effect like THC.

The processes for extracting CBD versus other products containing THC – even “hemp seed oil” which also contains very insignificant traces of THC – is very different as well as their applications and effects. (Just so you know, hemp seed oil is made from cold-pressing of hemp seeds whereas most CBD oils are made from the CO2 (non-toxic) cooling extraction process. Thus hemp seed oils are rather filtered where CBD oils are incredibly pure, resulting in the full-spectrum, the valuable cannabinoids and terpenes of the hemp plant preserved. Hemp seed oils are rich in cholesterol-lowering plant sterols and vitamin E, beneficial for their healthy source of monounsaturated and essential fatty acids, but the high amounts of CBD in our products support well-being, balancing/harmonizing the body’s natural systems as well as treating paint, discomfort and moods.)

Interesting Fact: Not mentioned in the video, as of March 2017, doctors have been allowed to prescribe medicines containing cannabis, such as flowers or extract, as a narcotic. This approval of THC doses, ranging between 100 to 22,000 mg, has been controversial since THC has been criticized for having addictive effects and harmful properties, but...

Remember! CBD contains less than 0.2% THC. Therefore, CBD is legally available and is increasingly easy to purchase in the EU as well as Norway, Switzerland and Iceland. Also, it is commonly offered as a dietary supplement or for cosmetic purposes.

In summary: Marijuana versus Hemp?

There is a vast, indisputable research available showing that CBD has far greater health benefits and aids far more medical problems than THC. If you’re still not sure though about whether to go with CBD or THC, we recommend reading Nordic Oil’s wiki page, “THC vs. CBD: Which One Should You Use?” They conclude,

We cannot conclusively say that CBD is better than THC. The use of the marijuana plant has different effects for different people. Things like genetic make-up, for example, drug use history and personal expectations dictate preference.

However, research shows that THC is very potent compared to CBD. The catch is here though; research shows that the low potency of CBD could also mean that it has little clinical benefits.

No single component of the marijuana plant can be conclusively labeled as good or bad. So for us to conclusively say that CBD is better than THC, a lot of research is required. It is most important to note that CBD has very little side effects. Apart from some people complaining of a dry mouth, the side effects of CBD is very minimal compared to the clinical benefits of CBD.

On the other hand, THC has a higher number of side effects. The side effects include anxiety and paranoia. CBD can be used to cure psychotic disorders. THC cannot be substituted for CBD and be used to mitigate psychotic disorders.

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Side Effects of CBD

Although this is not breaking news, we are frequently asked about the side effects of cannabidiol (CBD), especially with the concerns of side effects to its sister tetrahydrocannabinol (THC). If you check out our other article “Will CBD Get You High?“, you will find that the answer is no. THC, found in marijuana and hashish, will get you high and may also cause anxiety and paranoia. On the other hand, CBD is extracted from hemp and, aapart from some people complaining of a dry mouth, its side effects are incredibly minimal compared to the clinical benefits of CBD.

As mentioned, the important difference is that CBD is not psychotropic like THC; it does not induce a euphoric effect, otherwise known as a “high”. Now to elaborate… THC directly interacts with CB1 and CB2 receptors throughout your body whereas CBD works alongside them. To review from our Cannabidiol: The Ultimate Guide to CBD, your body’s endocannabinoid system is involved in regulating pain, immune system, sleep, appetite and much more. So in other words, the body produces endocannabinoids that bind to cannabinoid receptors in your nervous system. CB1 receptors are located in the nervous system (connective tissues, gonads, glands and organs) but there are also CB2 receptors in the immune system (spleen, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs), which is why scientists are, for instance, fascinated with the benefits of CBD for inhibiting the growth of tumors. (Researchers today suspect that there may even be a third cannabinoid receptor which has yet to be discovered!) In other words, the endocannabinoid system regulates many bodily functions. The peculiarity of the cannabinoid receptors is their location. To explain, your nervous system is built of transmitters and receptors, i.e. first and secondary cells. So, normally, receptors are located at the secondary cell to forward the signal on. However, oddly, the cannabinoid receptors are located on the former, i.e. the transmitter cell. This means that CBD is not directly responsible for the forwarding of the signal, but the transmitter cell retrograde, that is, returns information in a retrograde manner. Cannabinoids thus provide feedback to the transmitter cell. The messengers of the endocannabinoid system are therefore referred to as retrograde neurotransmitters or neuromodulators. So although CBD has little direct binding affinity for CB1 and CB2 receptors, it can influence the actual information transferred, also modulating several non-cannabinoid receptors and ion channels. Essentially, CBD works alongside the CB1 and CB2 receptors, such as by enhancing or inhibiting the binding action of certain G-protein coupled receptors. For example, Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London have found that CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect. Another example, CBD binds to TRPV1 receptors, which also function as ion channels, TRPV1 being known for mediating pain perception, inflammation and body temperature. To sum up, THC directly binds to CB1 receptors in the brain. This alters how the brain functions, affecting coordination, pleasure and cognitive abilities, thus causing the high. However, CBD does not directly bind to the CB1 receptors directly but still greatly supports and enhances the whole endocannabinoid system. For this reason, it doesn’t have the psychoactive effect like THC.

CBD contains less than 0.2% THC. This means that marijuana contains up to 33 times more THC. Studies further indicate that CBD contains anti-psychoactive properties that can counter the euphoric feeling found in THC and psychoactive cannabinoid. Again, THC brings about the euphoric effect when it binds with CB1 receptor located in the brain but CBD reverses this process by blocking the receptors from connecting with THC.

So what are some of the side effects of using CBD?

CBD is tolerant and poses no danger to humans.

A research according to WebMD shows that it is safe to use 300 mg dosage of CBD daily for six months and that a person can use up to 1500 mg of CBD daily without any harm for up to four weeks. HOWEVER, we have found that the average user only needs about 25 mg per day.The same studies indicate that a person can use up to 1500 mg of CBD daily without any harm for up to four weeks. According to other health sites, some of the people who have used CBD have reported symptoms such as dry mouth, low blood pressure, drowsiness and feeling lightheaded. Another research investigating the safety and effects of using CBD shows that there is NO adverse physiologically affects on:

  • Glucose levels
  • Body temperature
  • Exchange of carbon dioxide and oxygen between the bloodstream and lungs
  • pH levels
  • Red blood cell volume
  • Vomiting action
  • Sodium and Potassium levels
  • The time it takes for nutrients to leave your stomach and travel through the digestive system

Note: Some of our research has claimed that CBD has no impact on heart rate, but some of our research has claimed that CBD can slightly lower your heart rate, thus leading to the calming effect, not to be confused with the state of relaxation caused by THC. In any case, there have been no reports of increasing heart rate.

As mentioned in our article “What You Need to Generally Know About CBD Dosage“, when beginning CBD, it is best to start with a small dose. It is very important to become familiar with how your body responds to CBD before increasing the dose. We always advise our customers that every person is different and everyone’s reaction to CBD is different. On an average, 25mg of CBD a day is effective for most people. The dosage of CBD can be increased slowly until the symptoms improve. If a higher dosage is ultimately desired, consider a product with a higher CBD content.

If you are using any other medications, it is advisable to continue taking them until speaking further with your doctor.Original Article

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Quick Hits

Some recent highlights and curiosities from the amazing world of cannabis science and therapeutics:

  • CBD and autism. In his first article of the new year, Raphael Mechoulam and other Israeli scientists look at the “real life experiences of medical cannabis treatment in autism.” Published in Nature, the study found that just under a third of patients report significant improvements and over half report moderate improvements while using CBD-rich oil derived from cannabis (30% CBD, 1-2% THC). The improvements include decreased aggression and agitation, fewer seizures, and better sleep, appetite and ability to concentrate. Around 10-20% of patients stopped taking various medications (mostly antipsychotic and antiepileptic drugs) within 6 months of starting cannabis treatment. One quarter of people experienced some negative side effects like sedation or restlessness, but none were severe. And about one in 5 stopped treatment because it wasn’t effective. Even though there remains a lot to be discovered about how and why CBD can improve the lives of people with autism, it is clear that cannabis can be used safely by this population and should be studied further.
  • Cannabis and ADHD. A study in Molecular Psychiatry with tens of thousands of people found an association between ADHD and cannabis use. Their data suggests that ADHD causes later cannabis use, which may support the notion that THC is used to self medicate (although ADHD is associated with heavier use of many drugs). Previous research has found that THC may be effective for some cases that do not respond well to Ritalin.
  • Self medicating for endometriosis. Endometriosis is a poorly-understood condition causing severe chronic pain and alterations in a woman’s menstrual cycle. As an understudied disease, treatment is limited. Scientists surveyed over 400 Australian women to see what actions they took to treat their pelvic pain. Cannabis, heat, CBD oil, and dietary changes were rated most effective by women, in that order. Unfortunately, more women used alcohol than cannabis to manage symptoms; self-medicating with alcohol promotes chronic inflammation and led to worsening pain and fatigue in over half of such women. This underscores the importance of not treating cannabis like alcohol in the ongoing saga of legalization. (Note: endometriosis is diagnosed with an invasive surgical procedure, and so many women who likely have endometriosis go undiagnosed. The group that responded to this survey had a confirmed diagnosis.)
  • Concussions and alcoholism. Traumatic brain injury (TBI) leads to numerous problems, including alcoholism and suicide. New findings indicate that endocannabinoids aid TBI recovery: When researchers boosted 2-AG levels shortly after injury, rats displayed less anxiety and less interest in alcohol. This is significant since alcoholism is a serious comorbidity of brain injury. The researchers link the protective effect of 2-AG to changes in glutamate transmission in the central amygdala, the part of the brain that processes traumatic and fearful memories. Other preclinical research has demonstrated that endocannabinoids can play a protective role after traumatic brain injuries, like concussion, by ameliorating glutamatergic toxicity.

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Project CBD Releases Educational Primer on Cannabinoid-Drug Interactions

New: This report is now available in Spanish and Japanese translations! See bottom of this article for downloads.

Project CBD, a California-based educational non-profit, has published an in-depth primer on Cannabinoid-Drug Interactions for health professionals, patients, and public policy-makers. The 33-page report, summarized below, is available for free download at the bottom of the page.

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